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Title: STUDY ON THE PROTECTIVE EFFECT OF METHANOLIC EXTRACT OF MENTHA ARVENSIS L. LEAVES ON HALOPERIDOL INDUCED EXTRAPYRAMIDAL MOVEMENT DISORDERS IN ALBINO RATS

Description:

Anti-psychotics are the drugs used to treat schizophrenia. Typical anti-psychotics like haloperidol produce serious side effects called extrapyramidal movement disorders (EPS)
(catalepsy, tardive dyskinesia, acute dystonia, exploratory behaviour etc.), leading to patient noncompliance and loss of quality of life. These EPS are due to pro-oxidant property of haloperidol which causes oxidative stress induced neuronal damage. So, by the use of anti-oxidants EPS can be reduced.
In the present study, EPS are induced in four groups of albino rats by treating with haloperidol for 21 days,at a dose of 1mg/kg I.P. On the 22nd day three groups of albino rats were treated with MEMA 200mg/kg, 400mg/kg, 600mg/kg respectively. After 30 minutes of administration,haloperidol was injected. The fourth group was treated with haloperidol alone. The therapeutic effect of MEMA on haloperidol induced adverse effects was determined by various methods like hole board test, cataleptic score, and vacuous chewing movements and comparing the (Haloperidol+MEMA) treated groups with Haloperidol treated group.
High dose of MEMA showed a beneficiary effect by reducing the haloperidol induced adverse effects in albino rats. Thus, supplementation of MEMA along with haloperidol showed a protective effect over oxidative stress induced neuronal damage in albino rats.