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A recent study concerning Coenzyme Q10 and its effects on patients with heart failure has recently been made, with surprising results. The study, made in Copenhagen, Denmark, has found that Coenzyme Q10, or simply CoQ10, decreases mortality caused by heart failure by at least 50%, according to the results of a multicenter randomized double blind trial presented at the Heart Failure 2013 congress. It is the first drug known to man that can improve heart failure mortality found in over a decade. Researchers stressed that CoQ10 should be included in the treatment for those suffering from heart failure.

CoQ10 occurs naturally in the body and is essential for the creation of energy in the form of ATP, which is also needed for survival. CoQ10 works as an electron carrier in the mitochondria, the powerhouse of the cells, to produce energy, and is also a powerful antioxidant. It is the only antioxidant that humans are capable of synthesizing inside their bodies. CoQ10 levels decrease in the heart muscle of patients during episodes of heart failure, with the deficiency becoming more pronounced as heart failure severity worsens. Statins are used to treat many patients with heart failure because they block the synthesis of cholesterol, but these drugs also block the synthesis of CoQ10, which further decreases levels in the body.

The controlled trials have shown that CoQ10 improves the symptoms, functional capacity and quality of life in patients with heart failure with no side effects whatsoever. The Q-SYMBIO studyrandomized 420 patients with severe heart failure to CoQ10 or placebo and followed their progress for 2 years. The primary endpoint was the time for the first major adverse cardiovascular event (MACE), which may also have included an unplanned hospitalization due to worsening heart failure, cardiovascular death, urgent cardiac transplantation and mechanical circulatory support.

CoQ10 halved the risk of MACE, with 14% of the patients in the CoQ10 group reaching the primary endpoint compared to 25% of the patients in the placebo group. CoQ10 has also been found to have halved the risk of dying from all causes, which occurred in 9% amongst patients in the CoQ10 group compared to 17% of the patients in the placebo group. Heart failure patients treated with CoQ10 also had significantly lower cardiovascular mortality and lower occurrence of hospitalizations for heart failure. There were also fewer adverse events in the CoQ10 group compared to the placebo group.

CoQ10 is present in food, primarily in red meat, plants and fish, but levels are insufficient to make an impact on heart failure. CoQ10 is sold over the counter as dietary supplements, such as our PLATINUM Series CoQ10. Researchers, however, stress that dietary supplements can influence the effect of other medications, including anticoagulants, so it is important that patients seek advice from their doctors first before taking them.

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